MDS3/YGL197W Summary

MDS3 BASIC INFORMATION

Standard Name	MDS3
Systematic Name	YGL197W
Feature Type	ORF, Verified
Description	Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions (1, 2)
Name Description	Mck1 Dosage Suppressor 1

GO Annotations	All MDS3 GO evidence and references
	View Computational GO annotations for MDS3
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	negative regulation of sporulation resulting in formation of a cellular spore (IGI, IMP)
Cellular Component
High-throughput	cytoplasm (IDA) mitochondrion (IDA)

Mutant Phenotype	All MDS3 Phenotype details and references
Classical genetics
null	resistance to caffeine: decreased
Large-scale survey
null	hyperosmotic stress resistance: decreased resistance to ethanol: decreased viable

Interactions	MDS3 All interactions details and references
	28 total interaction(s) for 17 unique genes/features.
Physical Interactions	Affinity Capture-MS: 18 Affinity Capture-RNA: 1 Protein-RNA: 1 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 1 Synthetic Growth Defect: 2 Synthetic Rescue: 2

Sequence Information

ChrVII:124703 to 129166 | |

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..4464	124703..129166	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003165

MDS3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MDS3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MDS3]

1)	Benni ML and Neigeborn L (1997) Identification of a new class of negative regulators affecting sporulation-specific gene expression in yeast. Genetics 147(3):1351-66
2)	Davis DA, et al. (2002) Candida albicans Mds3p, a conserved regulator of pH responses and virulence identified through insertional mutagenesis. Genetics 162(4):1573-81

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