Standard Name	GCN1
Systematic Name	YGL195W
Alias	NDR1 1 , AAS103 1
Feature Type	ORF, Verified
Description	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA (2, 3)
Name Description	General Control Nonderepressible 4

Chromosomal Location	ChrVII:131525 to 139543 | ORF Map | GBrowse

	View Computational GO annotations for GCN1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	regulation of translational elongation (IMP, IPI)
Cellular Component
Manually curated	cytosol (IDA) cytosolic ribosome (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	hyperosmotic stress resistance: increased Sui2p modification: decreased resistance to paromomycin: increased resistance to amitrole: decreased viable
overexpression	resistance to paromomycin: decreased
reduction of function	dityrosine accumulation: decreased GCN4-lacZ activity: decreased thermotolerance: decreased vegetative growth: decreased
Large-scale survey
null	acid pH resistance: decreased competitive fitness: decreased resistance to bleomycin: increased resistance to camptothecin: increased resistance to tunicamycin: increased resistance to ethanol: decreased resistance to sulfometuron methyl: decreased resistance to hydroxyurea: decreased resistance to St. John's Wort extract: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	394 total interaction(s) for 281 unique genes/features.
Physical Interactions	Affinity Capture-MS: 91 Affinity Capture-RNA: 3 Affinity Capture-Western: 8 Co-fractionation: 3 PCA: 5 Reconstituted Complex: 3 Two-hybrid: 9
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 207 Positive Genetic: 51 Synthetic Growth Defect: 9 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:131525 to 139543 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..8019 131525..139543 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003163