Standard Name	HUR1 1
Systematic Name	YGL168W
Feature Type	ORF, Verified
Description	Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene (1, 2, 3)
Name Description	HydroxyUrea Resistance 1

Chromosomal Location	ChrVII:187464 to 187796 | ORF Map | GBrowse

	View Computational GO annotations for HUR1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	DNA replication (IMP)
Cellular Component
Manually curated	cellular_component unknown (ND)

Classical genetics
null	autophagy: decreased lithium(1+) accumulation: decreased chromosome/plasmid maintenance: abnormal ionic stress resistance: increased metal resistance: decreased mitophagy: decreased carboxypeptidase Y (Prc1p) modification: decreased
Large-scale survey
null	recombinant viral RNA accumulation: increased acid pH resistance: decreased alkaline pH resistance: decreased auxotrophy glycogen accumulation: decreased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased heat sensitivity: increased metal resistance: decreased oxidative stress resistance: decreased resistance to benzo[a]pyrene: increased resistance to streptomycin: decreased resistance to amitrole: decreased resistance to cycloheximide: decreased resistance to sirolimus: increased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to monensin: decreased resistance to hydroxyurea: decreased resistance to sulfometuron methyl: decreased resistance to tunicamycin: decreased resistance to wortmannin: decreased resistance to hydrogen chloride: decreased resistance to quinine: decreased resistance to boric acid: decreased resistance to dimethyl sulfoxide: decreased resistance to chloroquine: decreased resistance to cisplatin: decreased respiratory growth: decreased rate stress resistance: decreased telomere length: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	270 total interaction(s) for 194 unique genes/features.
Physical Interactions	Biochemical Activity: 1
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 211 Positive Genetic: 23 Synthetic Growth Defect: 23 Synthetic Lethality: 11
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:187464 to 187796 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..333 187464..187796 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003136