Standard Name	SUT1 1 (see Nomenclature conflict Note)
Systematic Name	YGL162W
Feature Type	ORF, Verified
Description	Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress; SUT1 has a paralog, SUT2, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	Sterol UpTake 1

Chromosomal Location	ChrVII:198138 to 199037 | ORF Map | GBrowse

	View Computational GO annotations for SUT1
Molecular Function
Manually curated	RNA polymerase II repressing transcription factor binding (IGI, IPI)
Biological Process
Manually curated	positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter (IMP)
Cellular Component
Manually curated	nucleus (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Binding motifs	Predicted SUT1 Binding Site Locations
	CGCG 3 [Search intergenic regions for CGCG] GCSGSGNNSG 6 [Search intergenic regions for GCSGSGNNSG]
Regulatory modules	predicted: cellcycle (383)
Resources	ScerTF | YeTFaSCo

Classical genetics
overexpression	AUS1-lacZ accumulation: increased
Large-scale survey
null	competitive fitness: decreased hyperosmotic stress resistance: decreased resistance to benzo[a]pyrene: increased resistance to nickel sulfate: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	70 total interaction(s) for 55 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 4 PCA: 2 Protein-RNA: 1 Reconstituted Complex: 1 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 46 Phenotypic Suppression: 1 Positive Genetic: 8 Synthetic Growth Defect: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:198138 to 199037 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..900 198138..199037 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003130