NUT1/YGL151W Summary Help

Standard Name NUT1 1
Systematic Name YGL151W
Alias MED5 2 , SSX4 3
Feature Type ORF, Verified
Description Component of the RNA polymerase II mediator complex; mediator is required for transcriptional activation and also has a role in basal transcription (4, 5)
Name Description Negative regulation of URS Two 1
Chromosomal Location
ChrVII:217524 to 220922 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All NUT1 GO evidence and references
  View Computational GO annotations for NUT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
372 total interaction(s) for 263 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 82
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 9
  • Co-purification: 1
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 206
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 3
  • Positive Genetic: 25
  • Synthetic Growth Defect: 25
  • Synthetic Lethality: 7
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,132
Molecular Weight (Da) 128,793
Isoelectric Point (pI) 4.86
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:217524 to 220922 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3399 217524..220922 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003119
References cited on this page View Complete Literature Guide for NUT1
1) Tabtiang RK and Herskowitz I  (1998) Nuclear proteins Nut1p and Nut2p cooperate to negatively regulate a Swi4p-dependent lacZ reporter gene in Saccharomyces cerevisiae. Mol Cell Biol 18(8):4707-18
2) Bourbon HM, et al.  (2004) A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell 14(5):553-7
3) Li L, et al.  (2005) Genetic interactions between mediator and the late G1-specific transcription factor Swi6 in Saccharomyces cerevisiae. Genetics 171(2):477-88
4) Gustafsson CM, et al.  (1998) Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae. J Biol Chem 273(47):30851-4
5) Guglielmi B, et al.  (2004) A high resolution protein interaction map of the yeast Mediator complex. Nucleic Acids Res 32(18):5379-91