INO80/YGL150C Summary

INO80 BASIC INFORMATION

Standard Name	INO80 1
Systematic Name	YGL150C
Feature Type	ORF, Verified
Description	ATPase, subunit of a complex containing actin and several actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription (1, 2, 3, 4)
Name Description	INOsitol requiring

GO Annotations	All INO80 GO evidence and references
	View Computational GO annotations for INO80
Molecular Function
Manually curated	contributes_to ATP-dependent 3'-5' DNA helicase activity (IDA) ATPase activity (IDA)
Biological Process
Manually curated	chromatin remodeling (IDA) chromatin silencing at telomere (IMP) DNA repair (IDA, IMP) nucleosome mobilization (IMP) positive regulation of gene-specific transcription from RNA polymerase II promoter (IMP) regulation of transcription from RNA polymerase II promoter in response to stress (IMP) transcription from RNA polymerase II promoter (IDA, IMP)
Cellular Component
Manually curated	Ino80 complex (IDA)

Mutant Phenotype	All INO80 Phenotype details and references
Classical genetics
null	auxotrophy resistance to methyl methanesulfonate: decreased utilization of carbon source: absent viable
Large-scale survey
null	inviable resistance to sulfanilamide: decreased vegetative growth: decreased

Interactions	INO80 All interactions details and references
	120 total interaction(s) for 48 unique genes/features.
Physical Interactions	Affinity Capture-MS: 86 Affinity Capture-RNA: 1 Affinity Capture-Western: 10 Two-hybrid: 3
Genetic Interactions	Phenotypic Enhancement: 14 Synthetic Growth Defect: 4 Synthetic Lethality: 2

Sequence Information

ChrVII:225578 to 221109 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..4470	225578..221109	2004-07-20	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003118

INO80 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for INO80

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for INO80]

1)	Ebbert R, et al. (1999) The product of the SNF2/SWI2 paralogue INO80 of Saccharomyces cerevisiae required for efficient expression of various yeast structural genes is part of a high-molecular-weight protein complex. Mol Microbiol 32(4):741-51
2)	Shen X, et al. (2000) A chromatin remodelling complex involved in transcription and DNA processing. Nature 406(6795):541-4
3)	Shen X, et al. (2003) Involvement of actin-related proteins in ATP-dependent chromatin remodeling. Mol Cell 12(1):147-55
4)	Klopf E, et al. (2009) Cooperation between the INO80 complex and histone chaperones determines adaptation of stress gene transcription in the yeast Saccharomyces cerevisiae. Mol Cell Biol 29(18):4994-5007

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