INO80/YGL150C Summary Help

Standard Name INO80 1
Systematic Name YGL150C
Feature Type ORF, Verified
Description ATPase and nucleosome spacing factor; subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; promotes nucleosome shifts in the 3 prime direction; has a role in modulating stress gene transcription (1, 2, 3, 4, 5, 6)
Name Description INOsitol requiring
Chromosomal Location
ChrVII:225573 to 221104 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All INO80 GO evidence and references
  View Computational GO annotations for INO80
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Classical genetics
Large-scale survey
206 total interaction(s) for 90 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 118
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 14
  • Co-purification: 11
  • Reconstituted Complex: 5
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 37
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 2
  • Positive Genetic: 2
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 3

Expression Summary
Length (a.a.) 1,489
Molecular Weight (Da) 171,454
Isoelectric Point (pI) 5.54
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:225573 to 221104 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..4470 225573..221104 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003118
References cited on this page View Complete Literature Guide for INO80
1) Ebbert R, et al.  (1999) The product of the SNF2/SWI2 paralogue INO80 of Saccharomyces cerevisiae required for efficient expression of various yeast structural genes is part of a high-molecular-weight protein complex. Mol Microbiol 32(4):741-51
2) Shen X, et al.  (2000) A chromatin remodelling complex involved in transcription and DNA processing. Nature 406(6795):541-4
3) Shen X, et al.  (2003) Involvement of actin-related proteins in ATP-dependent chromatin remodeling. Mol Cell 12(1):147-55
4) Klopf E, et al.  (2009) Cooperation between the INO80 complex and histone chaperones determines adaptation of stress gene transcription in the yeast Saccharomyces cerevisiae. Mol Cell Biol 29(18):4994-5007
5) Udugama M, et al.  (2011) The INO80 ATP-dependent chromatin remodeling complex is a nucleosome spacing factor. Mol Cell Biol 31(4):662-73
6) Yen K, et al.  (2012) Genome-wide nucleosome specificity and directionality of chromatin remodelers. Cell 149(7):1461-73