Standard Name	TIP20 1 (see Nomenclature conflict Note)
Systematic Name	YGL145W
Alias	TIP1 2
Feature Type	ORF, Verified
Description	Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p (3, 4)
Name Description	SEC20 (Twenty) Interacting Protein 2

Chromosomal Location	ChrVII:230243 to 232348 | ORF Map | GBrowse

	View Computational GO annotations for TIP20
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	retrograde vesicle-mediated transport, Golgi to ER (IGI)
Cellular Component
Manually curated	Dsl1p complex (IDA) endoplasmic reticulum (IDA)

Classical genetics
conditional	heat sensitivity: increased
null	inviable
repressible	endoplasmic reticulum morphology: abnormal carboxypeptidase Y (CPY) accumulation: increased
unspecified	inviable
Large-scale survey
null	inviable resistance to mefloquine: decreased
reduction of function	competitive fitness: increased
repressible	chromosome/plasmid maintenance: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	83 total interaction(s) for 27 unique genes/features.
Physical Interactions	Affinity Capture-MS: 23 Affinity Capture-Western: 15 Co-fractionation: 2 Reconstituted Complex: 6 Two-hybrid: 25
Genetic Interactions	Dosage Lethality: 1 Phenotypic Suppression: 1 Positive Genetic: 1 Synthetic Lethality: 9
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:230243 to 232348 | ORF Map | GBrowse
	This feature contains embedded feature(s): ARS701
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2106 230243..232348 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003113