SEC27/YGL137W Summary Help

SEC27 BASIC INFORMATION

Standard Name SEC27 1
Systematic Name YGL137W
Feature Type ORF, Verified
Description Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP (1, 2, 3)
Name Description SECretory
GO Annotations All SEC27 GO evidence and references
    View Computational GO annotations for SEC27
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SEC27 Phenotype details and references
Classical genetics
conditional
null
repressible
Large-scale survey
null
repressible
Interactions SEC27 All interactions details and references
254 total interaction(s) for 163 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 115
  • Affinity Capture-Western: 2
  • PCA: 25
  • Protein-peptide: 1
  • Reconstituted Complex: 2
Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 6
  • Phenotypic Enhancement: 88
  • Phenotypic Suppression: 8
  • Synthetic Lethality: 5
Sequence Information
ChrVII:249874 to 252743 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..18 249874..249891 2004-07-20 1996-07-31
Intron 19..218 249892..250091 2004-07-20 1996-07-31
CDS 219..2870 250092..252743 2004-07-20 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003105

SEC27 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SEC27

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SEC27]

1) Duden R, et al.  (1994) Yeast beta- and beta'-coat proteins (COP). Two coatomer subunits essential for endoplasmic reticulum-to-Golgi protein traffic. J Biol Chem 269(39):24486-95
2) Letourneur F, et al.  (1994) Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum. Cell 79(7):1199-207
3) Eugster A, et al.  (2004) The alpha- and beta'-COP WD40 domains mediate cargo-selective interactions with distinct di-lysine motifs. Mol Biol Cell 15(3):1011-23