ITC1/YGL133W Summary

ITC1 BASIC INFORMATION

Standard Name	ITC1
Systematic Name	YGL133W
Feature Type	ORF, Verified
Description	Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1 (1, 2, 3)

GO Annotations	All ITC1 GO evidence and references
	View Computational GO annotations for ITC1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	chromatin remodeling (TAS) chromatin silencing at telomere (IMP) negative regulation of transcription from RNA polymerase II promoter by pheromones (IMP)
Cellular Component
Manually curated	chromatin accessibility complex (IPI)

Mutant Phenotype	All ITC1 Phenotype details and references
Classical genetics
null	invasive growth: increased Slt2p modification: increased
Large-scale survey
null	viable

Interactions	ITC1 All interactions details and references
	95 total interaction(s) for 70 unique genes/features.
Physical Interactions	Affinity Capture-MS: 33 Affinity Capture-RNA: 1 Affinity Capture-Western: 4 Co-localization: 2 PCA: 4
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 29 Phenotypic Suppression: 12 Synthetic Growth Defect: 5 Synthetic Lethality: 2 Synthetic Rescue: 2

Sequence Information

ChrVII:257712 to 261506 | |

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3795	257712..261506	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003101

ITC1 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ITC1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ITC1]

1)	Goldmark JP, et al. (2000) The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p. Cell 103(3):423-33
2)	Sugiyama M and Nikawa J (2001) The Saccharomyces cerevisiae Isw2p-Itc1p complex represses INO1 expression and maintains cell morphology. J Bacteriol 183(17):4985-93
3)	Ruiz C, et al. (2003) Cell-type-dependent repression of yeast a-specific genes requires Itc1p, a subunit of the Isw2p-Itc1p chromatin remodelling complex. Microbiology 149(Pt 2):341-51

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.