SNT2/YGL131C Summary Help

Standard Name SNT2
Systematic Name YGL131C
Feature Type ORF, Verified
Description Subunit of Snt2C complex, RING finger ubiquitin ligase (E3); physically associates with Ecm5p and Rpd3p; along with Ecm5p, recruits Rpd3p to small number of promoters; colocalizes with Ecm5p, independently of Rpd3p, to promoters of stress response genes upon oxidative stress; involved in ubiquitylation, degradation of excess histones; interacts with Ubc4p; role in regulating genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress (1, 2, 3, 4, 5, 6, 7)
Chromosomal Location
ChrVII:265859 to 261648 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All SNT2 GO evidence and references
  View Computational GO annotations for SNT2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Regulators 5 genes
Classical genetics
Large-scale survey
29 total interaction(s) for 24 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 6
  • Biochemical Activity: 1
  • Reconstituted Complex: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 10
  • Phenotypic Enhancement: 1
  • Positive Genetic: 3

Expression Summary
Length (a.a.) 1,403
Molecular Weight (Da) 163,202
Isoelectric Point (pI) 8.56
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:265859 to 261648 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..4212 265859..261648 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003099
References cited on this page View Complete Literature Guide for SNT2
1) Roguev A, et al.  (2004) A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. Mol Cell Proteomics 3(2):125-32
2) Harbison CT, et al.  (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431(7004):99-104
3) Ward LD and Bussemaker HJ  (2008) Predicting functional transcription factor binding through alignment-free and affinity-based analysis of orthologous promoter sequences. Bioinformatics 24(13):i165-71
4) Yang Y, et al.  (2010) Identifying cooperative transcription factors by combining ChIP-chip data and knockout data. Cell Res 20(11):1276-8
5) Singh RK, et al.  (2012) Novel E3 Ubiquitin Ligases That Regulate Histone Protein Levels in the Budding Yeast Saccharomyces cerevisiae. PLoS One 7(5):e36295
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
7) Baker LA, et al.  (2013) The yeast snt2 protein coordinates the transcriptional response to hydrogen peroxide-mediated oxidative stress. Mol Cell Biol 33(19):3735-48