ABC1/YGL119W Summary Help

ABC1 BASIC INFORMATION

Standard Name ABC1
Systematic Name YGL119W
Alias COQ8
Feature Type ORF, Verified
Description Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis (1, 2, 3, 4)
Name Description Activity of BC(1) complex 2
GO Annotations All ABC1 GO evidence and references
    View Computational GO annotations for ABC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All ABC1 Phenotype details and references
Classical genetics
null
reduction of function
Interactions ABC1 All interactions details and references
9 total interaction(s) for 7 unique genes/features.
Physical Interactions
  • Affinity Capture-Western: 1
  • Biochemical Activity: 2
  • Two-hybrid: 2
Genetic Interactions
  • Dosage Rescue: 3
  • Phenotypic Suppression: 1
Sequence Information
ChrVII:284448 to 285953 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1506 284448..285953 2004-07-20 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003087

ABC1 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for ABC1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ABC1]

1) Poon WW, et al.  (2000) Identification of Escherichia coli ubiB, a gene required for the first monooxygenase step in ubiquinone biosynthesis. J Bacteriol 182(18):5139-46
2) Bousquet I, et al.  (1991) ABC1, a novel yeast nuclear gene has a dual function in mitochondria: it suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex. EMBO J 10(8):2023-31
3) Do TQ, et al.  (2001) A defect in coenzyme Q biosynthesis is responsible for the respiratory deficiency in Saccharomyces cerevisiae abc1 mutants. J Biol Chem 276(21):18161-8
4) Johnson A, et al.  (2005) COQ9, a new gene required for the biosynthesis of coenzyme Q in Saccharomyces cerevisiae. J Biol Chem 280(36):31397-404