Standard Name	ARC1
Systematic Name	YGL105W
Feature Type	ORF, Verified
Description	Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5, 6)
Name Description	Acyl-RNA-Complex

Chromosomal Location	ChrVII:307437 to 308567 | ORF Map | GBrowse

	View Computational GO annotations for ARC1
Molecular Function
Manually curated	enzyme activator activity (IDA) phosphatidylinositol-3,5-bisphosphate binding (IDA) phosphatidylinositol-3-phosphate binding (IDA) tRNA binding (IMP, IPI)
Biological Process
Manually curated	positive regulation of ligase activity (IDA) tRNA aminoacylation for protein translation (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) methionyl glutamyl tRNA synthetase complex (IMP, IPI)

Classical genetics
null	cold sensitivity: increased vegetative growth: decreased viable
Large-scale survey
null	competitive fitness: decreased fermentative growth: decreased rate filamentous growth: decreased heat sensitivity: increased invasive growth: absent ionic stress resistance: decreased metal resistance: decreased oxidative stress resistance: decreased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to cycloheximide: decreased resistance to paromomycin: decreased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to mycophenolic acid: decreased resistance to dihydromotuporamine C: decreased resistance to acetaldehyde: decreased sporulation: decreased stress resistance: increased transposable element transposition: increased viable
overexpression	cell cycle progression in G1 phase: abnormal vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	215 total interaction(s) for 181 unique genes/features.
Physical Interactions	Affinity Capture-MS: 45 Affinity Capture-RNA: 2 Affinity Capture-Western: 4 Biochemical Activity: 21 Co-crystal Structure: 2 PCA: 3 Reconstituted Complex: 8
Genetic Interactions	Dosage Rescue: 4 Negative Genetic: 69 Positive Genetic: 51 Synthetic Growth Defect: 2 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:307437 to 308567 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1131 307437..308567 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003073