LSG1/YGL099W Summary Help

Standard Name LSG1 1
Systematic Name YGL099W
Alias KRE35
Feature Type ORF, Verified
Description Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm (1, 2)
Name Description Large-Subunit Gtpase 1
Chromosomal Location
ChrVII:314631 to 316553 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All LSG1 GO evidence and references
  View Computational GO annotations for LSG1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
reduction of function
Resources
150 total interaction(s) for 67 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 73
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 53
  • Biochemical Activity: 2
  • Co-purification: 9
  • PCA: 4
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 4
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 640
Molecular Weight (Da) 72,727
Isoelectric Point (pI) 9.45
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:314631 to 316553 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1923 314631..316553 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003067
References cited on this page View Complete Literature Guide for LSG1
1) Kallstrom G, et al.  (2003) The putative GTPases Nog1p and Lsg1p are required for 60S ribosomal subunit biogenesis and are localized to the nucleus and cytoplasm, respectively. Mol Cell Biol 23(12):4344-55
2) Hedges J, et al.  (2005) Release of the export adapter, Nmd3p, from the 60S ribosomal subunit requires Rpl10p and the cytoplasmic GTPase Lsg1p. EMBO J 24(3):567-79