Standard Name	USE1 1
Systematic Name	YGL098W
Alias	SLT1 2
Feature Type	ORF, Verified
Description	Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p (1, 2)
Name Description	Unconventional SNARE in the ER 1

Chromosomal Location	ChrVII:317342 to 318079 | ORF Map | GBrowse

	View Computational GO annotations for USE1
Molecular Function
Manually curated	SNAP receptor activity (ISA)
Biological Process
Manually curated	retrograde vesicle-mediated transport, Golgi to ER (IMP) vesicle fusion with endoplasmic reticulum (IC)
Cellular Component
Manually curated	integral to cytosolic side of endoplasmic reticulum membrane (IDA) SNARE complex (IDA, ISM)

Classical genetics
null	inviable
Large-scale survey
conditional	colony sectoring: increased resistance to methyl methanesulfonate: decreased
null	haploproficient inviable
reduction of function	competitive fitness: decreased
repressible	mitochondrial morphology: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	114 total interaction(s) for 71 unique genes/features.
Physical Interactions	Affinity Capture-MS: 18 Affinity Capture-RNA: 2 Affinity Capture-Western: 18 Co-fractionation: 2 Co-purification: 1 PCA: 1 Reconstituted Complex: 2 Two-hybrid: 7
Genetic Interactions	Negative Genetic: 45 Positive Genetic: 2 Synthetic Growth Defect: 8 Synthetic Lethality: 8
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:317342 to 318079 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..738 317342..318079 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003066