VPS45/YGL095C Summary Help

VPS45 BASIC INFORMATION

Standard Name VPS45 1
Systematic Name YGL095C
Alias STT10 2 , VPL28 1
Feature Type ORF, Verified
Description Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment (3, 4, 5)
Name Description Vacuolar Protein Sorting 1
GO Annotations All VPS45 GO evidence and references
    View Computational GO annotations for VPS45
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All VPS45 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions VPS45 All interactions details and references
63 total interaction(s) for 47 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 7
  • PCA: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 5
Genetic Interactions
  • Dosage Rescue: 3
  • Phenotypic Enhancement: 7
  • Synthetic Growth Defect: 21
  • Synthetic Lethality: 7
Sequence Information
ChrVII:330610 to 328877 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1734 330610..328877 2004-07-20 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003063

VPS45 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for VPS45

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for VPS45]

1) Raymond CK, et al.  (1992) Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol Biol Cell 3(12):1389-402
2) Yoshida S, et al.  (1995) STT10, a novel class-D VPS yeast gene required for osmotic integrity related to the PKC1/STT1 protein kinase pathway. Gene 160(1):117-22
3) Piper RC, et al.  (1994) Yeast Vps45p is a Sec1p-like protein required for the consumption of vacuole-targeted, post-Golgi transport vesicles. Eur J Cell Biol 65(2):305-18
4) Bryant NJ, et al.  (1998) Traffic into the prevacuolar/endosomal compartment of Saccharomyces cerevisiae: a VPS45-dependent intracellular route and a VPS45-independent, endocytic route. Eur J Cell Biol 76(1):43-52
5) Bryant NJ and James DE  (2001) Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation. EMBO J 20(13):3380-8