SPC105/YGL093W Summary

SPC105 BASIC INFORMATION

Standard Name	SPC105
Systematic Name	YGL093W
Feature Type	ORF, Verified
Description	Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components (1, 2)
Name Description	Spindle Pole Component 3

GO Annotations	All SPC105 GO evidence and references
	View Computational GO annotations for SPC105
Molecular Function
Manually curated	microtubule binding (IDA) structural constituent of cytoskeleton (IPI)
Biological Process
Manually curated	microtubule nucleation (IPI) mitotic cell cycle spindle assembly checkpoint (IMP) protein localization to kinetochore (IMP) sister chromatid biorientation (IMP)
Cellular Component
Manually curated	condensed nuclear chromosome kinetochore (IDA) spindle pole body (IDA)
High-throughput	mitochondrion (IDA)

Mutant Phenotype	All SPC105 Phenotype details and references
Classical genetics
conditional	chromosome segregation: abnormal colony sectoring: decreased heat sensitivity: increased
null	inviable
Large-scale survey
null	inviable

Interactions	SPC105 All interactions details and references
	24 total interaction(s) for 16 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-Western: 6 Co-fractionation: 1 Co-localization: 1 Co-purification: 1 Reconstituted Complex: 1 Two-hybrid: 5
Genetic Interactions	Synthetic Lethality: 1

Sequence Information

ChrVII:334889 to 337642 | |

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2754	334889..337642	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003061

SPC105 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SPC105

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SPC105]

1)	Nekrasov VS, et al. (2003) Interactions between centromere complexes in Saccharomyces cerevisiae. Mol Biol Cell 14(12):4931-46
2)	Pagliuca C, et al. (2009) Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint. PLoS One 4(10):e7640
3)	Wigge PA, et al. (1998) Analysis of the Saccharomyces spindle pole by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. J Cell Biol 141(4):967-77

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