MF(ALPHA)2/YGL089C Summary Help

Standard Name MF(ALPHA)2 1, 2
Systematic Name YGL089C
Feature Type ORF, Verified
Description Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed; MF(ALPHA)2 has a paralog, MF(ALPHA)1, that arose from the whole genome duplication (1, 3, 4)
Name Description Mating Factor ALPHA 5
Chromosomal Location
ChrVII:345153 to 344791 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -58 cM
  View Computational GO annotations for MF(ALPHA)2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 12 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
6 total interaction(s) for 6 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Co-purification: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 120
Molecular Weight (Da) 13,271
Isoelectric Point (pI) 4.67
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:345153 to 344791 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: -58 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..363 345153..344791 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003057
References cited on this page View Complete Literature Guide for MF(ALPHA)2
1) Singh A, et al.  (1983) Saccharomyces cerevisiae contains two discrete genes coding for the alpha-factor pheromone. Nucleic Acids Res 11(12):4049-63
2) Shari, C. and Kurjan, J.  (1985) Personal Communication, Mortimer Map Edition 9
3) Kurjan J  (1985) Alpha-factor structural gene mutations in Saccharomyces cerevisiae: effects on alpha-factor production and mating. Mol Cell Biol 5(4):787-96
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Kurjan J and Herskowitz I  (1982) Structure of a yeast pheromone gene (MF alpha): a putative alpha-factor precursor contains four tandem copies of mature alpha-factor. Cell 30(3):933-43