Standard Name	GUP1 1
Systematic Name	YGL084C
Feature Type	ORF, Verified
Description	Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport; GUP1 has a paralog, GUP2, that arose from the whole genome duplication (2, 3, 4, 5, 6)
Name Description	Glycerol UPtake 1

Chromosomal Location	ChrVII:352298 to 350616 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for GUP1
Molecular Function
Manually curated	O-acyltransferase activity (IMP)
Biological Process
Manually curated	glycerol catabolic process (IGI, IMP) glycerol transport (IGI, IMP) GPI anchor biosynthetic process (IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IDA) membrane (IDA, ISS) plasma membrane (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
misexpression	resistance to sorbic acid: decreased
null	cell wall morphology: abnormal (1->3)-beta-D-glucan accumulation: increased mannoproteins accumulation: decreased lithium(1+) accumulation: decreased reactive oxygen species accumulation: increased chitin deposition: increased chronological lifespan: decreased heat sensitivity: increased inviable Gas1p transport: abnormal Gas1p modification: decreased resistance to FK506: decreased resistance to Calcofluor White: decreased resistance to caffeine: decreased resistance to sodium dodecyl sulfate: decreased resistance to benzoic acid: decreased resistance to acetic acid: decreased resistance to ethanol: decreased resistance to potassium chloride: decreased resistance to caffeine and glucitol: increased
overexpression	endomembrane system morphology: abnormal
Large-scale survey
null	anaerobic growth: decreased budding pattern: abnormal cell shape: abnormal cell size: decreased glycogen accumulation: increased chitin deposition: increased competitive fitness: decreased endocytosis: decreased fermentative growth: decreased rate haploinsufficient heat sensitivity: increased ionic stress resistance: decreased protein transport: abnormal resistance to cisplatin: decreased resistance to calcium dichloride: decreased resistance to hygromycin B: decreased resistance to mefloquine: decreased resistance to dimethyl sulfoxide: decreased resistance to bleomycin: decreased resistance to pentachlorophenol: decreased resistance to methyl methanesulfonate: decreased resistance to sodium arsenite: decreased resistance to hydrogen chloride: decreased resistance to acetic acid: decreased resistance to (S)-lactic acid: decreased resistance to FK506: decreased resistance to arsenite(3-): decreased resistance to 5-fluorouracil: decreased resistance to amiodarone: decreased resistance to Calcofluor White: decreased resistance to mycophenolic acid: increased resistance to fluconazole: increased resistance to fenpropimorph: increased resistance to cycloheximide: increased resistance to camptothecin: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to paromomycin: decreased resistance to streptomycin: decreased resistance to doxorubicin: decreased respiratory growth: decreased rate small molecule transport: decreased telomere length: decreased toxin resistance: decreased vacuolar morphology: abnormal vegetative growth: absent viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	358 total interaction(s) for 221 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 2 Biochemical Activity: 2 PCA: 4
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 1 Negative Genetic: 230 Phenotypic Enhancement: 4 Positive Genetic: 75 Synthetic Growth Defect: 21 Synthetic Lethality: 13 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:352298 to 350616 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1683 352298..350616 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000003052