GUP1/YGL084C Summary Help

Standard Name GUP1 1
Systematic Name YGL084C
Feature Type ORF, Verified
Description Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; role in misfolded protein quality control; proposed to be involved in glycerol transport; GUP1 has a paralog, GUP2, that arose from the whole genome duplication (2, 3, 4, 5, 6, 7)
Name Description Glycerol UPtake 1
Chromosomal Location
ChrVII:352298 to 350616 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All GUP1 GO evidence and references
  View Computational GO annotations for GUP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Classical genetics
Large-scale survey
480 total interaction(s) for 281 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • Biochemical Activity: 2
  • PCA: 4
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 1
  • Negative Genetic: 322
  • Phenotypic Enhancement: 4
  • Positive Genetic: 100
  • Synthetic Growth Defect: 21
  • Synthetic Lethality: 13
  • Synthetic Rescue: 4

Expression Summary
Length (a.a.) 560
Molecular Weight (Da) 65,339
Isoelectric Point (pI) 10.3
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:352298 to 350616 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1683 352298..350616 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000003052
References cited on this page View Complete Literature Guide for GUP1
1) Holst B, et al.  (2000) GUP1 and its close homologue GUP2, encoding multimembrane-spanning proteins involved in active glycerol uptake in Saccharomyces cerevisiae. Mol Microbiol 37(1):108-24
2) Neves L, et al.  (2004) New insights on glycerol transport in Saccharomyces cerevisiae. FEBS Lett 565(1-3):160-2
3) Bleve G, et al.  (2005) Subcellular localization and functional expression of the glycerol uptake protein 1 (GUP1) of Saccharomyces cerevisiae tagged with green fluorescent protein. Biochem J 390(Pt 1):145-55
4) Hofmann K  (2000) A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling. Trends Biochem Sci 25(3):111-2
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Bosson R, et al.  (2006) GUP1 of Saccharomyces cerevisiae encodes an O-acyltransferase involved in remodeling of the GPI anchor. Mol Biol Cell 17(6):2636-45
7) Copic A, et al.  (2009) Genomewide analysis reveals novel pathways affecting endoplasmic reticulum homeostasis, protein modification and quality control. Genetics 182(3):757-69