MPC1/YGL080W Summary Help

Standard Name MPC1 1, 2
Systematic Name YGL080W
Alias FMP37 3 , 4
Feature Type ORF, Verified
Description Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Mpc1p and either Mpc2p or Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia (1, 2, 5, 6)
Name Description Mitochondrial Pyruvate Carrier 1, 2
Chromosomal Location
ChrVII:358636 to 359028 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MPC1 GO evidence and references
  View Computational GO annotations for MPC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
repressible
Resources
49 total interaction(s) for 42 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 3

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 30
  • Positive Genetic: 4
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 130
Molecular Weight (Da) 14,995
Isoelectric Point (pI) 10.27
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:358636 to 359028 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..393 358636..359028 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003048
References cited on this page View Complete Literature Guide for MPC1
1) Bricker DK, et al.  (2012) A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science 337(6090):96-100
2) Herzig S, et al.  (2012) Identification and functional expression of the mitochondrial pyruvate carrier. Science 337(6090):93-6
3) Rehling, P., et al.  (2004) personal communication
4) Kawahata M, et al.  (2006) Yeast genes involved in response to lactic acid and acetic acid: acidic conditions caused by the organic acids in Saccharomyces cerevisiae cultures induce expression of intracellular metal metabolism genes regulated by Aft1p. FEMS Yeast Res 6(6):924-36
5) Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54
6) Heinicke S, et al.  (2007) The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists. PLoS One 2(8):e766