FMP37/YGL080W Summary Help

Standard Name FMP37 1, 2
Systematic Name YGL080W
Alias MPC1 3 , 4
Feature Type ORF, Verified
Description Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia (3, 4, 5, 6)
Name Description Found in Mitochondrial Proteome 1
Chromosomal Location
ChrVII:358636 to 359028 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All FMP37 GO evidence and references
  View Computational GO annotations for FMP37
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
repressible
Resources
49 total interaction(s) for 42 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 3

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 30
  • Positive Genetic: 4
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 130
Molecular Weight (Da) 14,995
Isoelectric Point (pI) 10.27
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:358636 to 359028 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..393 358636..359028 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003048
References cited on this page View Complete Literature Guide for FMP37
1) Rehling, P., et al.  (2004) personal communication
2) Kawahata M, et al.  (2006) Yeast genes involved in response to lactic acid and acetic acid: acidic conditions caused by the organic acids in Saccharomyces cerevisiae cultures induce expression of intracellular metal metabolism genes regulated by Aft1p. FEMS Yeast Res 6(6):924-36
3) Bricker DK, et al.  (2012) A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science 337(6090):96-100
4) Herzig S, et al.  (2012) Identification and functional expression of the mitochondrial pyruvate carrier. Science 337(6090):93-6
5) Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54
6) Heinicke S, et al.  (2007) The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists. PLoS One 2(8):e766