KXD1/YGL079W Summary Help

Standard Name KXD1 1
Systematic Name YGL079W
Feature Type ORF, Verified
Description Subunit of the BLOC-1 complex involved in endosomal maturation; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome (1, 2, 3, 4)
Name Description KxDL homologue 1
Chromosomal Location
ChrVII:359444 to 360100 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All KXD1 GO evidence and references
  View Computational GO annotations for KXD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Large-scale survey
null
Resources
40 total interaction(s) for 31 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 3
  • Biochemical Activity: 5
  • Two-hybrid: 19

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 218
Molecular Weight (Da) 24,442
Isoelectric Point (pI) 4.08
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:359444 to 360100 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..657 359444..360100 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Retired NameKIB1
Primary SGDIDS000003047
References cited on this page View Complete Literature Guide for KXD1
1) Hayes MJ, et al.  (2011) Yeast Homologues of Three BLOC-1 Subunits Highlight KxDL Proteins As Conserved Interactors of BLOC-1. Traffic 12(3):260-8
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Norambuena L, et al.  (2008) Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae. BMC Chem Biol 8:1
4) John Peter AT, et al.  (2013) The BLOC-1 complex promotes endosomal maturation by recruiting the Rab5 GTPase-activating protein Msb3. J Cell Biol 201(1):97-111