DBP3/YGL078C Summary Help

Standard Name DBP3
Systematic Name YGL078C
Feature Type ORF, Verified
Description RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype (1, 2)
Name Description Dead Box Protein
Chromosomal Location
ChrVII:361859 to 360288 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All DBP3 GO evidence and references
  View Computational GO annotations for DBP3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
154 total interaction(s) for 115 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 40
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • PCA: 5

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 54
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 42
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 523
Molecular Weight (Da) 58,826
Isoelectric Point (pI) 9.91
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:361859 to 360288 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1572 361859..360288 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003046
References cited on this page View Complete Literature Guide for DBP3
1) Weaver PL, et al.  (1997) Dbp3p, a putative RNA helicase in Saccharomyces cerevisiae, is required for efficient pre-rRNA processing predominantly at site A3. Mol Cell Biol 17(3):1354-65
2) Garcia I and Uhlenbeck OC  (2008) Differential RNA-Dependent ATPase Activities of Four rRNA Processing Yeast DEAD-Box Proteins (dagger). Biochemistry 47(47):12562-73