MPS2/YGL075C Summary

MPS2 BASIC INFORMATION

Standard Name	MPS2 1
Systematic Name	YGL075C
Alias	MMC1
Feature Type	ORF, Verified
Description	Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p (2, 3)
Name Description	MonoPolar Spindle 1, 2

GO Annotations	All MPS2 GO evidence and references
	View Computational GO annotations for MPS2
Molecular Function
Manually curated	structural constituent of cytoskeleton (IMP)
Biological Process
Manually curated	mitotic anaphase (TAS) spindle pole body duplication in nuclear envelope (IMP)
Cellular Component
Manually curated	nuclear envelope (IDA) spindle pole body (IDA)

Mutant Phenotype	All MPS2 Phenotype details and references
Classical genetics
overexpression	budding index: abnormal cell cycle progression in G2 phase: abnormal
unspecified	cell cycle progression in G2 phase: arrested heat sensitivity: increased
Large-scale survey
null	inviable
overexpression	inviable
repressible	cell cycle progression: abnormal

Interactions	MPS2 All interactions details and references
	56 total interaction(s) for 35 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-Western: 4 Biochemical Activity: 4 Co-localization: 1 Co-purification: 2 Reconstituted Complex: 3 Two-hybrid: 21
Genetic Interactions	Dosage Rescue: 7 Synthetic Lethality: 8 Synthetic Rescue: 5

Sequence Information

ChrVII:368091 to 366928 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1164	368091..366928	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003043

MPS2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MPS2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MPS2]

1)	Winey M, et al. (1991) MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication. J Cell Biol 114(4):745-54
2)	Munoz-Centeno MC, et al. (1999) Saccharomyces cerevisiae MPS2 encodes a membrane protein localized at the spindle pole body and the nuclear envelope. Mol Biol Cell 10(7):2393-406
3)	Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64

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