YBP2/YGL060W Summary Help

Standard Name YBP2 1
Systematic Name YGL060W
Alias YBH1 2
Feature Type ORF, Verified
Description Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication (2, 3, 4)
Name Description Yap1-Binding Protein 1
Chromosomal Location
ChrVII:390065 to 391990 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YBP2 GO evidence and references
  View Computational GO annotations for YBP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Classical genetics
conditional
null
Large-scale survey
null
Resources
71 total interaction(s) for 57 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 16
  • Two-hybrid: 9

Genetic Interactions
  • Negative Genetic: 26
  • Phenotypic Enhancement: 1
  • Positive Genetic: 1
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 8
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 641
Molecular Weight (Da) 73,101
Isoelectric Point (pI) 5.03
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:390065 to 391990 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1926 390065..391990 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003028
References cited on this page View Complete Literature Guide for YBP2
1) Veal EA, et al.  (2003) Ybp1 is required for the hydrogen peroxide-induced oxidation of the Yap1 transcription factor. J Biol Chem 278(33):30896-904
2) Gulshan K, et al.  (2004) YBP1 and its homologue YBP2/YBH1 influence oxidative-stress tolerance by nonidentical mechanisms in Saccharomyces cerevisiae. Eukaryot Cell 3(2):318-30
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Ohkuni K, et al.  (2008) Ybp2 Associates with the Central Kinetochore of Saccharomyces cerevisiae and Mediates Proper Mitotic Progression. PLoS One 3(2):e1617