Standard Name	PKP2 1
Systematic Name	YGL059W
Feature Type	ORF, Verified
Description	Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress (1, 2, 3, 4)
Name Description	Protein Kinase of PDH 1

Chromosomal Location	ChrVII:392223 to 393698 | ORF Map | GBrowse

	View Computational GO annotations for PKP2
Molecular Function
Manually curated	protein kinase activity (IDA) pyruvate dehydrogenase (acetyl-transferring) kinase activity (IMP)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	carbon utilization (IGI) negative regulation of catalytic activity (IMP) peptidyl-serine phosphorylation (IMP)
High-throughput	protein phosphorylation (IDA)
Cellular Component
Manually curated	mitochondrion (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	growth in exponential phase: decreased rate pyruvate dehydrogenase complex activity: increased Pda1p subunit of pyruvate dehydrogenase complex modification: decreased
Large-scale survey
null	competitive fitness: decreased resistance to cycloheximide: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	121 total interaction(s) for 118 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 92
Genetic Interactions	Negative Genetic: 15 Phenotypic Enhancement: 1 Positive Genetic: 5 Synthetic Growth Defect: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | AspGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:392223 to 393698 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1476 392223..393698 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003027