TYW3/YGL050W Summary Help

Standard Name TYW3 1
Systematic Name YGL050W
Feature Type ORF, Verified
Description tRNA methyltransferase required for synthesis of wybutosine; a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions (1, 2)
Name Description Trna-YW synthesizing protein 1
Chromosomal Location
ChrVII:405776 to 406597 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TYW3 GO evidence and references
  View Computational GO annotations for TYW3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
unspecified
Resources
11 total interaction(s) for 11 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 3

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 273
Molecular Weight (Da) 30,806
Isoelectric Point (pI) 8.04
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:405776 to 406597 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..822 405776..406597 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003018
References cited on this page View Complete Literature Guide for TYW3
1) Noma A, et al.  (2006) Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA. EMBO J 25(10):2142-54
2) Noma A and Suzuki T  (2006) Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis. Nucleic Acids Symp Ser (Oxf) (50):65-6