Standard Name	TIF4632 1
Systematic Name	YGL049C
Feature Type	ORF, Verified
Description	Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Translation Initiation Factor 1
Gene Product Alias	eIF4G2 5

Chromosomal Location	ChrVII:409604 to 406860 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for TIF4632
Molecular Function
Manually curated	mRNA binding (IDA) translation initiation factor activity (IDA, IMP) translation initiation factor binding (IMP, IPI)
Biological Process
Manually curated	stress granule assembly (IMP) translational initiation (IDA, IMP)
Cellular Component
Manually curated	cytoplasmic stress granule (IDA) eukaryotic translation initiation factor 4F complex (IGI, ISS)

Classical genetics
null	stress resistance: decreased viable
Large-scale survey
null	auxotrophy haploproficient resistance to caffeine: increased resistance to St. John's Wort extract: decreased resistance to fluconazole: increased resistance to tunicamycin: increased resistance to bleomycin: decreased resistance to camptothecin: decreased stress resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	131 total interaction(s) for 67 unique genes/features.
Physical Interactions	Affinity Capture-MS: 68 Affinity Capture-RNA: 2 Affinity Capture-Western: 13 PCA: 4 Reconstituted Complex: 15 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 12 Negative Genetic: 4 Phenotypic Suppression: 3 Positive Genetic: 2 Synthetic Growth Defect: 1 Synthetic Lethality: 2 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:409604 to 406860 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2745 409604..406860 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003017