TIF4632/YGL049C Summary Help

TIF4632 BASIC INFORMATION

Standard Name TIF4632 1
Systematic Name YGL049C
Feature Type ORF, Verified
Description Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4631p (1, 2, 3)
Name Description Translation Initiation Factor 1
Gene Product Alias eIF4G2 4
GO Annotations All TIF4632 GO evidence and references
    View Computational GO annotations for TIF4632
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All TIF4632 Phenotype details and references
Classical genetics
null
Large-scale survey
null
overexpression
Interactions TIF4632 All interactions details and references
95 total interaction(s) for 52 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 54
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 5
  • PCA: 3
  • Reconstituted Complex: 12
  • Two-hybrid: 2
Genetic Interactions
  • Dosage Rescue: 10
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1
Sequence Information
ChrVII:409607 to 406863 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2745 409607..406863 2004-07-20 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003017

TIF4632 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for TIF4632

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TIF4632]

1) Goyer C, et al.  (1993) TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function. Mol Cell Biol 13(8):4860-74
2) Tarun SZ Jr, et al.  (1997) Translation initiation factor eIF4G mediates in vitro poly(A) tail-dependent translation. Proc Natl Acad Sci U S A 94(17):9046-51
3) Dominguez D, et al.  (1999) Interaction of translation initiation factor eIF4G with eIF4A in the yeast Saccharomyces cerevisiae. J Biol Chem 274(38):26720-6
4) Neff CL and Sachs AB  (1999) Eukaryotic translation initiation factors 4G and 4A from Saccharomyces cerevisiae interact physically and functionally. Mol Cell Biol 19(8):5557-64