Standard Name	RPT6 1
Systematic Name	YGL048C
Alias	CIM3 2 , CRL3 , SCB68 , SUG1
Feature Type	ORF, Verified
Description	ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress (3, 4, 5, 6, 7)
Name Description	Regulatory Particle Triple-A protein, or Regulatory Particle Triphosphatase 1

Chromosomal Location	ChrVII:411286 to 410069 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -43 cM

	View Computational GO annotations for RPT6
Molecular Function
Manually curated	ATPase activity (ISS) protein domain specific binding (IDA)
Biological Process
Manually curated	chromatin remodeling (IMP) negative regulation of sequence-specific DNA binding transcription factor activity (IMP) nucleotide-excision repair (IGI) positive regulation of RNA polymerase II transcriptional preinitiation complex assembly (IGI, IMP) positive regulation of sequence-specific DNA binding transcription factor activity (IMP) positive regulation of transcription elongation from RNA polymerase II promoter (IMP) proteasomal ubiquitin-dependent protein catabolic process (IPI) proteasome regulatory particle assembly (IMP)
Cellular Component
Manually curated	nucleus (IDA) proteasome regulatory particle, base subcomplex (IDA) proteasome storage granule (IDA)

Classical genetics
conditional	cell cycle progression through the G2/M phase transition: arrested cell size: increased heat sensitivity: increased Matalpha1p accumulation: increased Fzo1p accumulation: increased Rrn3p accumulation: increased Pex5p modification: increased
null	heat sensitivity: increased resistance to L-canavanine: decreased vegetative growth: decreased
reduction of function	heat sensitivity: increased replicative lifespan: decreased resistance to canavanine: decreased
unspecified	resistance to cycloheximide: increased
Large-scale survey
null	haploinsufficient inviable resistance to clioquinol: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased
reduction of function	competitive fitness: decreased
repressible	chromosome/plasmid maintenance: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	310 total interaction(s) for 115 unique genes/features.
Physical Interactions	Affinity Capture-MS: 123 Affinity Capture-RNA: 3 Affinity Capture-Western: 49 Biochemical Activity: 1 Co-crystal Structure: 2 Co-fractionation: 4 Co-localization: 1 Co-purification: 10 PCA: 5 Reconstituted Complex: 13 Two-hybrid: 27
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 9 Phenotypic Enhancement: 3 Phenotypic Suppression: 3 Positive Genetic: 33 Synthetic Growth Defect: 8 Synthetic Lethality: 7 Synthetic Rescue: 8
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:411286 to 410069 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -43 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1218 411286..410069 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003016