RPT6/YGL048C Summary Help

RPT6 BASIC INFORMATION

Standard Name RPT6 1
Systematic Name YGL048C
Alias CIM3 2 , CRL3 , SCB68 , SUG1
Feature Type ORF, Verified
Description One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle (3, 4, 5, 6)
Name Description Regulatory Particle Triple-A protein, or Regulatory Particle Triphosphatase 1
GO Annotations All RPT6 GO evidence and references
    View Computational GO annotations for RPT6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All RPT6 Phenotype details and references
Classical genetics
conditional
reduction of function
unspecified
Large-scale survey
null
Interactions RPT6 All interactions details and references
247 total interaction(s) for 82 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 106
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 35
  • Biochemical Activity: 1
  • Co-fractionation: 4
  • Co-localization: 1
  • Co-purification: 9
  • PCA: 5
  • Reconstituted Complex: 10
  • Two-hybrid: 9
Genetic Interactions
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 11
  • Synthetic Lethality: 5
  • Synthetic Rescue: 46
Sequence Information
ChrVII:411289 to 410072 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -43 cM
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1218 411289..410072 2004-07-20 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003016

RPT6 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for RPT6

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RPT6]

1) Finley D, et al.  (1998) Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Trends Biochem Sci 23(7):244-5
2) Ghislain M, et al.  (1993) S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase. Nature 366(6453):358-62
3) Russell SJ, et al.  (1999) Subcellular localization, stoichiometry, and protein levels of 26 S proteasome subunits in yeast. J Biol Chem 274(31):21943-52
4) Xie Y and Varshavsky A  (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502
5) Glickman MH, et al.  (1999) Functional analysis of the proteasome regulatory particle. Mol Biol Rep 26(1-2):21-8
6) Rubin DM, et al.  (1998) Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome. EMBO J 17(17):4909-19