RIM8/YGL045W Summary Help

Standard Name RIM8 1
Systematic Name YGL045W
Alias PAL3 2 , YGL046W , ART9 3
Feature Type ORF, Verified
Description Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family (2, 3, 4, 5, 6)
Name Description Regulator of IME2 1
Chromosomal Location
ChrVII:414102 to 415730 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RIM8 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 7 genes
Resources
Classical genetics
conditional
null
unspecified
Large-scale survey
null
Resources
336 total interaction(s) for 248 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 247
  • Phenotypic Enhancement: 1
  • Positive Genetic: 36
  • Synthetic Growth Defect: 18
  • Synthetic Lethality: 12
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 542
Molecular Weight (Da) 60,864
Isoelectric Point (pI) 9.94
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:414102 to 415730 | ORF Map | GBrowse
This feature contains embedded feature(s): YGL046W
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2003-01-09
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1629 414102..415730 2011-02-03 2003-01-09
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003013
References cited on this page View Complete Literature Guide for RIM8
1) Su SS and Mitchell AP  (1993) Identification of functionally related genes that stimulate early meiotic gene expression in yeast. Genetics 133(1):67-77
2) Treton B, et al.  (2000) Ambient pH signalling in ascomycetous yeasts involves homologues of the Aspergillus nidulans genes palF and paIH. Mol Gen Genet 263(3):505-13
3) Lin CH, et al.  (2008) Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface. Cell 135(4):714-25
4) Li W and Mitchell AP  (1997) Proteolytic activation of Rim1p, a positive regulator of yeast sporulation and invasive growth. Genetics 145(1):63-73
5) Ishtar Snoek IS and Yde Steensma H  (2006) Why does Kluyveromyces lactis not grow under anaerobic conditions? Comparison of essential anaerobic genes of Saccharomyces cerevisiae with the Kluyveromyces lactis genome. FEMS Yeast Res 6(3):393-403
6) Herrador A, et al.  (2010) Recruitment of the ESCRT machinery to a putative seven-transmembrane-domain receptor is mediated by an arrestin-related protein. Mol Cell Biol 30(4):897-907