Standard Name	HOP2
Systematic Name	YGL033W
Feature Type	ORF, Verified
Description	Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair (1, 2)
Name Description	HOmologous Pairing 1

Chromosomal Location	ChrVII:435625 to 436351 | ORF Map | GBrowse

	View Computational GO annotations for HOP2
Molecular Function
Manually curated	double-stranded DNA binding (IDA, IPI) protein binding (IPI)
Biological Process
Manually curated	reciprocal meiotic recombination (IMP) synapsis (IMP)
Cellular Component
Manually curated	condensed nuclear chromosome (IDA)

Classical genetics
null	meiotic recombination: absent sporulation: absent
Large-scale survey
null	acid pH resistance: decreased bud morphology: abnormal cell size: increased proton accumulation: increased chitin deposition: decreased haploinsufficient resistance to benomyl: decreased sporulation: absent sporulation efficiency: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	33 total interaction(s) for 26 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Reconstituted Complex: 1 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 5 Negative Genetic: 6 Phenotypic Enhancement: 6 Phenotypic Suppression: 3 Positive Genetic: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 3 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:435625 to 436351 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2000-12-01
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..55 435625..435679 2011-02-03 2000-12-01 Intron 56..125 435680..435749 2011-02-03 2000-12-01 CDS 126..727 435750..436351 2011-02-03 2000-12-01
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (56 - 125)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003001