HOP2/YGL033W Summary Help

Standard Name HOP2 1
Systematic Name YGL033W
Feature Type ORF, Verified
Description Meiosis-specific protein that localizes to chromosomes;preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair; contains a second intron at the 3' end (in SK1 strain background); heterodimer of Hop2p-Mnd1p stimulates the activity of Dmc1p (1, 2, 3)
Name Description HOmologous Pairing 1
Chromosomal Location
ChrVII:435625 to 436351 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HOP2 GO evidence and references
  View Computational GO annotations for HOP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 12 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
34 total interaction(s) for 26 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 5
  • Negative Genetic: 6
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 3
  • Positive Genetic: 1
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 3
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 218
Molecular Weight (Da) 25,027
Isoelectric Point (pI) 4.78
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:435625 to 436351 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2000-12-01
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..55 435625..435679 2011-02-03 2000-12-01
Intron 56..125 435680..435749 2011-02-03 2000-12-01
CDS 126..727 435750..436351 2011-02-03 2000-12-01
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003001
References cited on this page View Complete Literature Guide for HOP2
1) Leu JY, et al.  (1998) The meiosis-specific Hop2 protein of S. cerevisiae ensures synapsis between homologous chromosomes. Cell 94(3):375-86
2) Tsubouchi H and Roeder GS  (2002) The Mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair. Mol Cell Biol 22(9):3078-88
3) Chan YL, et al.  (2014) The Third Exon of the Budding Yeast Meiotic Recombination Gene HOP2 Is Required for Calcium-dependent and Recombinase Dmc1-specific Stimulation of Homologous Strand Assimilation. J Biol Chem 289(26):18076-18086