Standard Name	GET1 1
Systematic Name	YGL020C
Alias	MDM39 2
Feature Type	ORF, Verified
Description	Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance (1, 2, 3)
Name Description	Guided Entry of Tailanchored proteins 3

Chromosomal Location	ChrVII:457870 to 457163 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for GET1
Molecular Function
Manually curated	protein anchor (IGI)
Biological Process
Manually curated	protein insertion into ER membrane (IGI) retrograde vesicle-mediated transport, Golgi to ER (IDA, IGI, IMP)
Cellular Component
Manually curated	GET complex (IPI) integral to membrane (ISM)
High-throughput	endoplasmic reticulum (IDA) mitochondrion (IDA)

Classical genetics
null	heat sensitivity: increased Hsp104p accumulation: increased resistance to copper(2+) sulfate: decreased resistance to hygromycin B: decreased resistance to hydroxyurea: decreased resistance to tunicamycin: decreased resistance to paromomycin: decreased resistance to tellurite: decreased
Large-scale survey
null	acid pH resistance: decreased auxotrophy glycogen accumulation: decreased competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased metal resistance: decreased mitochondrial morphology: abnormal oxidative stress resistance: decreased protein transport: abnormal resistance to hydroxyurea: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to sirolimus: decreased resistance to fluconazole: increased resistance to fenpropimorph: increased resistance to cycloheximide: increased resistance to wortmannin: increased resistance to cycloheximide: decreased resistance to neomycin: decreased resistance to ethanol: decreased resistance to 4-chlorophenol: decreased resistance to bleomycin: decreased resistance to caffeine: decreased resistance to mycophenolic acid: decreased resistance to tunicamycin: decreased resistance to sodium selenide: decreased resistance to ciclopirox olamine: decreased resistance to lovastatin: decreased resistance to L-1,4-dithiothreitol: decreased resistance to sorbate: decreased resistance to hygromycin B: decreased resistance to doxorubicin: decreased respiratory growth: decreased rate sporulation: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	1105 total interaction(s) for 539 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 1 Co-crystal Structure: 3 Co-fractionation: 1 PCA: 4 Reconstituted Complex: 3
Genetic Interactions	Dosage Lethality: 2 Negative Genetic: 549 Phenotypic Enhancement: 22 Phenotypic Suppression: 83 Positive Genetic: 127 Synthetic Growth Defect: 223 Synthetic Lethality: 76 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:457870 to 457163 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..708 457870..457163 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002988