GET1/YGL020C Summary Help

Standard Name GET1 1
Systematic Name YGL020C
Alias MDM39 2
Feature Type ORF, Verified
Description Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance (1, 2, 3)
Name Description Guided Entry of Tail-anchored proteins 3
Chromosomal Location
ChrVII:457870 to 457163 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All GET1 GO evidence and references
  View Computational GO annotations for GET1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
1112 total interaction(s) for 540 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Co-crystal Structure: 4
  • Co-fractionation: 1
  • PCA: 4
  • Reconstituted Complex: 4

Genetic Interactions
  • Dosage Lethality: 2
  • Negative Genetic: 549
  • Phenotypic Enhancement: 24
  • Phenotypic Suppression: 83
  • Positive Genetic: 127
  • Synthetic Growth Defect: 223
  • Synthetic Lethality: 76
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 235
Molecular Weight (Da) 27,092
Isoelectric Point (pI) 9.98
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:457870 to 457163 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..708 457870..457163 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002988
References cited on this page View Complete Literature Guide for GET1
1) Schuldiner M, et al.  (2005) Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123(3):507-19
2) Dimmer KS, et al.  (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53
3) Schuldiner M, et al.  (2008) The GET complex mediates insertion of tail-anchored proteins into the ER membrane. Cell 134(4):634-45