CKB1/YGL019W Summary

CKB1 BASIC INFORMATION

Standard Name	CKB1
Systematic Name	YGL019W
Feature Type	ORF, Verified
Description	Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases (1, 2)
Name Description	Casein Kinase Beta subunit

GO Annotations	All CKB1 GO evidence and references
	View Computational GO annotations for CKB1
Molecular Function
Manually curated	protein kinase regulator activity (IMP, IPI)
Biological Process
Manually curated	cellular ion homeostasis (IMP) establishment of cell polarity (IPI) flocculation via cell wall protein-carbohydrate interaction (IMP) G1/S transition of mitotic cell cycle (IPI) G2/M transition of mitotic cell cycle (IPI) protein amino acid phosphorylation (IDA) regulation of transcription from RNA polymerase I promoter (IDA) regulation of transcription from RNA polymerase III promoter (IDA) response to DNA damage stimulus (IDA)
Cellular Component
Manually curated	protein kinase CK2 complex (IDA) UTP-C complex (IDA)

Mutant Phenotype	All CKB1 Phenotype details and references
Classical genetics
null	ionic stress resistance: decreased
Large-scale survey
null	hyperosmotic stress resistance: decreased resistance to calcium dichloride: decreased resistance to caffeine: decreased resistance to sulfanilamide: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to ethanol: decreased resistance to doxorubicin: decreased sporulation: decreased viable

Interactions	CKB1 All interactions details and references
	230 total interaction(s) for 143 unique genes/features.
Physical Interactions	Affinity Capture-MS: 75 Affinity Capture-Western: 4 Biochemical Activity: 3 Co-purification: 1 PCA: 2 Reconstituted Complex: 3 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 94 Phenotypic Suppression: 32 Synthetic Growth Defect: 7 Synthetic Lethality: 4

Sequence Information

ChrVII:458161 to 458997 | |

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..837	458161..458997	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002987

CKB1 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for CKB1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CKB1]

1)	Ackermann K, et al. (2001) Genes targeted by protein kinase CK2: a genome-wide expression array analysis in yeast. Mol Cell Biochem 227(1-2):59-66
2)	Ahmed K, et al. (2002) Joining the cell survival squad: an emerging role for protein kinase CK2. Trends Cell Biol 12(5):226-30

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