KAP122/YGL016W Summary Help

Standard Name KAP122 1
Systematic Name YGL016W
Alias PDR6
Feature Type ORF, Verified
Description Karyopherin beta; responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance (1, 2)
Name Description KAryoPherin 1
Chromosomal Location
ChrVII:461666 to 464911 | ORF Map | GBrowse
Gbrowse
Genetic position: -10 cM
Gene Ontology Annotations All KAP122 GO evidence and references
  View Computational GO annotations for KAP122
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
99 total interaction(s) for 89 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 16
  • Affinity Capture-Western: 6
  • Co-localization: 4
  • Co-purification: 2
  • Reconstituted Complex: 3
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 45
  • Phenotypic Enhancement: 4
  • Positive Genetic: 9
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,081
Molecular Weight (Da) 123,530
Isoelectric Point (pI) 4.75
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:461666 to 464911 | ORF Map | GBrowse
SGD ORF map
Genetic position: -10 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3246 461666..464911 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002984
References cited on this page View Complete Literature Guide for KAP122
1) Titov AA and Blobel G  (1999) The karyopherin Kap122p/Pdr6p imports both subunits of the transcription factor IIA into the nucleus. J Cell Biol 147(2):235-46
2) Chen WN, et al.  (1991) The DNA sequencing of the 17 kb HindIII fragment spanning the LEU1 and ATE1 loci on chromosome VII from Saccharomyces cerevisiae reveals the PDR6 gene, a new member of the genetic network controlling pleiotropic drug resistance. Yeast 7(3):287-99