KAP122/YGL016W Summary

KAP122 BASIC INFORMATION

Standard Name	KAP122
Systematic Name	YGL016W
Alias	PDR6
Feature Type	ORF, Verified
Description	Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance (1, 2)
Name Description	KAryoPherin

GO Annotations	All KAP122 GO evidence and references
	View Computational GO annotations for KAP122
Molecular Function
Manually curated	protein transporter activity (IMP, IPI)
Biological Process
Manually curated	protein import into nucleus (IDA, IMP)
High-throughput	regulation of cell size (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nuclear pore (IDA)

Mutant Phenotype	All KAP122 Phenotype details and references
Classical genetics
null	Rnr4p distribution: abnormal
Large-scale survey
null	hyperosmotic stress resistance: decreased resistance to ethanol: decreased viable
overexpression	vegetative growth: decreased

Interactions	KAP122 All interactions details and references
	46 total interaction(s) for 41 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-Western: 6 Co-localization: 4 Co-purification: 1 Reconstituted Complex: 2 Two-hybrid: 2
Genetic Interactions	Phenotypic Enhancement: 8 Phenotypic Suppression: 6 Synthetic Growth Defect: 2 Synthetic Lethality: 1 Synthetic Rescue: 1

Sequence Information

ChrVII:461671 to 464916 | |

Genetic position: -10 cM

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3246	461671..464916	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002984

KAP122 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for KAP122

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for KAP122]

1)	Chen WN, et al. (1991) The DNA sequencing of the 17 kb HindIII fragment spanning the LEU1 and ATE1 loci on chromosome VII from Saccharomyces cerevisiae reveals the PDR6 gene, a new member of the genetic network controlling pleiotropic drug resistance. Yeast 7(3):287-99
2)	Titov AA and Blobel G (1999) The karyopherin Kap122p/Pdr6p imports both subunits of the transcription factor IIA into the nucleus. J Cell Biol 147(2):235-46

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