ERG4/YGL012W Summary 
| Standard Name | ERG4 |
|---|---|
| Systematic Name | YGL012W |
| Feature Type | ORF, Verified |
| Description | C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol (1, 2, 3, 4 and see Summary Paragraph) |
| Name Description | ERGosterol biosynthesis |
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Gene Ontology Annotations All ERG4 GO evidence and references
| View Computational GO annotations for ERG4 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated | |
| High-throughput |
| Pathways |
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Mutant phenotypes All ERG4 Phenotype evidence and references
interactions All ERG4 Interaction evidence and references
| 216 total interaction(s) for 117 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All ERG4 Protein evidence and references
| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
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| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
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Analyze Sequence
| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000002980 |
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SUMMARY PARAGRAPH for ERG4
ERG4 encodes sterol C-24(28) reductase, which catalyzes the final step in ergosterol biosynthesis (3, 4, 1, 2). Cells lacking ERG4 are viable, but lack ergosterol and are sensitive to several drugs (3, 5, 6). A mutation in ERG4 increases expression of ERG3, which encodes another enzyme involved in ergosterol biosynthesis (7). The S. pombe gene sts1 encodes a protein similar to Erg4p (8).
Last updated: 2000-09-06 
References cited on this page View Complete Literature Guide for ERG4
| 1) | Lees ND, et al. (1995) Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. Lipids 30(3):221-6 |
| 2) | Parks LW, et al. (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30 |
| 3) | Zweytick D, et al. (2000) Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast saccharomyces cerevisiae. FEBS Lett 470(1):83-7 |
| 4) | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
| 5) | Sauer B (1992) Identification of cryptic lox sites in the yeast genome by selection for Cre-mediated chromosome translocations that confer multiple drug resistance. J Mol Biol 223(4):911-28 |
| 6) | Kaur R and Bachhawat AK (1999) The yeast multidrug resistance pump, Pdr5p, confers reduced drug resistance in erg mutants of Saccharomyces cerevisiae. Microbiology 145 ( Pt 4)():809-18 |
| 7) | Arthington-Skaggs BA, et al. (1996) Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway. FEBS Lett 392(2):161-5 |
| 8) | Shimanuki M, et al. (1992) Fission yeast sts1+ gene encodes a protein similar to the chicken lamin B receptor and is implicated in pleiotropic drug-sensitivity, divalent cation-sensitivity, and osmoregulation. Mol Biol Cell 3(3):263-73 |
