URC2/YDR520C Summary Help

Standard Name URC2 1
Systematic Name YDR520C
Alias RRT4 2
Feature Type ORF, Uncharacterized
Description Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism (1, 2, 3, 4)
Name Description URacil Catabolism 1
Chromosomal Location
ChrIV:1483403 to 1481085 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All URC2 GO evidence and references
  View Computational GO annotations for URC2
Molecular Function
High-throughput
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
38 total interaction(s) for 35 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Protein-peptide: 1
  • Two-hybrid: 11

Genetic Interactions
  • Negative Genetic: 21
  • Positive Genetic: 1
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 772
Molecular Weight (Da) 88,647
Isoelectric Point (pI) 7.9
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1483403 to 1481085 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2319 1483403..1481085 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002928
References cited on this page View Complete Literature Guide for URC2
1) Andersen G, et al.  (2008) A second pathway to degrade pyrimidine nucleic acid precursors in eukaryotes. J Mol Biol 380(4):656-66
2) Hontz RD, et al.  (2009) Genetic Identification of Factors That Modulate Ribosomal DNA Transcription in Saccharomyces cerevisiae. Genetics 182(1):105-19
3) Akache B, et al.  (2001) Phenotypic analysis of genes encoding yeast zinc cluster proteins. Nucleic Acids Res 29(10):2181-90
4) Guo X, et al.  (2006) Histone acetylation and transcriptional regulation in the genome of Saccharomyces cerevisiae. Bioinformatics 22(4):392-9
5) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66
6) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87