Standard Name	URC2 1
Systematic Name	YDR520C
Alias	RRT4 2
Feature Type	ORF, Uncharacterized
Description	Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism (1, 2, 3, 4)
Name Description	URacil Catabolism 1

Chromosomal Location	ChrIV:1483403 to 1481085 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for URC2
Molecular Function
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	uracil catabolic process (ISS)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Binding motifs	CGGAGATA 5 [Search intergenic regions for CGGAGATA] HCGGANWTA 6 [Search intergenic regions for HCGGANWTA]
Resources	ScerTF | UniProbe | YeTFaSCo

Classical genetics
null	resistance to caffeine: decreased viable
overexpression	metal resistance: increased
Large-scale survey
null	competitive fitness: decreased resistance to oligomycin: normal resistance to 4-nitroquinoline N-oxide: normal resistance to rhodamine 6-G: normal resistance to cycloheximide: normal resistance to chloramphenicol: normal resistance to ketoconazole: normal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	38 total interaction(s) for 35 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Protein-peptide: 1 Two-hybrid: 11
Genetic Interactions	Negative Genetic: 21 Positive Genetic: 1 Synthetic Growth Defect: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1483403 to 1481085 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2319 1483403..1481085 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002928