FPR2/YDR519W Summary Help

Standard Name FPR2
Systematic Name YDR519W
Alias FKB2
Feature Type ORF, Verified
Description Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress (1, 2, 3, 4)
Name Description FKBP Proline Rotamase
Chromosomal Location
ChrIV:1480425 to 1480832 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All FPR2 GO evidence and references
  View Computational GO annotations for FPR2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
23 total interaction(s) for 22 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 4
  • Co-purification: 1
  • PCA: 1

Genetic Interactions
  • Negative Genetic: 5
  • Phenotypic Enhancement: 1
  • Positive Genetic: 3
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 135
Molecular Weight (Da) 14,487
Isoelectric Point (pI) 5.23
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1480425 to 1480832 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..408 1480425..1480832 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002927
References cited on this page View Complete Literature Guide for FPR2
1) Partaledis JA and Berlin V  (1993) The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum. Proc Natl Acad Sci U S A 90(12):5450-4
2) Partaledis JA, et al.  (1992) Saccharomyces cerevisiae contains a homolog of human FKBP-13, a membrane-associated FK506/rapamycin binding protein. Yeast 8(8):673-80
3) Nielsen JB, et al.  (1992) Yeast FKBP-13 is a membrane-associated FK506-binding protein encoded by the nonessential gene FKB2. Proc Natl Acad Sci U S A 89(16):7471-5
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76