EUG1/YDR518W Summary Help

Standard Name EUG1 1
Systematic Name YDR518W
Feature Type ORF, Verified
Description Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER (1, 2, 3)
Name Description ER protein Unnecessary for Growth 1
Chromosomal Location
ChrIV:1478608 to 1480161 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All EUG1 GO evidence and references
  View Computational GO annotations for EUG1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
129 total interaction(s) for 116 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 83
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 12
  • Positive Genetic: 21
  • Synthetic Haploinsufficiency: 1
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 517
Molecular Weight (Da) 58,982
Isoelectric Point (pI) 4.63
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1478608 to 1480161 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1554 1478608..1480161 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002926
References cited on this page View Complete Literature Guide for EUG1
1) Tachibana C and Stevens TH  (1992) The yeast EUG1 gene encodes an endoplasmic reticulum protein that is functionally related to protein disulfide isomerase. Mol Cell Biol 12(10):4601-11
2) Holst B, et al.  (1997) Active site mutations in yeast protein disulfide isomerase cause dithiothreitol sensitivity and a reduced rate of protein folding in the endoplasmic reticulum. J Cell Biol 138(6):1229-38
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61