Standard Name	SMT3
Systematic Name	YDR510W
Feature Type	ORF, Verified
Description	Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2 (1, 2, 3, 4, 5, 6, 7, 8)
Name Description	Suppressor of Mif Two

Chromosomal Location	ChrIV:1469400 to 1469705 | ORF Map | GBrowse

Molecular Function
Manually curated	protein tag (IDA, ISS)
Biological Process
Manually curated	protein sumoylation (IDA)
Cellular Component
Manually curated	condensed nuclear chromosome (IDA) nucleus (IDA) septin ring (IDA)

Classical genetics
dominant negative	pseudohyphal growth: increased
overexpression	Mot1p modification: increased
unspecified	Matalpha1p accumulation: increased
Large-scale survey
conditional	colony sectoring: increased
null	inviable
overexpression	vegetative growth: decreased
reduction of function	competitive fitness: decreased resistance to methyl methanesulfonate: decreased telomere length: increased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	1729 total interaction(s) for 989 unique genes/features.
Physical Interactions	Affinity Capture-MS: 834 Affinity Capture-RNA: 3 Affinity Capture-Western: 169 Biochemical Activity: 13 Co-crystal Structure: 4 Co-localization: 1 Co-purification: 2 PCA: 375 Protein-peptide: 3 Reconstituted Complex: 20 Two-hybrid: 100
Genetic Interactions	Dosage Growth Defect: 3 Dosage Rescue: 5 Negative Genetic: 31 Phenotypic Suppression: 5 Positive Genetic: 5 Synthetic Growth Defect: 144 Synthetic Lethality: 7 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1469400 to 1469705 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..306 1469400..1469705 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002918