Standard Name	LCD1 1
Systematic Name	YDR499W
Alias	DDC2 2 , PIE1 3
Feature Type	ORF, Verified
Description	Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress (1, 3, 4)
Name Description	Lethal, Checkpoint-defective, DNA damage sensitive 1

Chromosomal Location	ChrIV:1447830 to 1450073 | ORF Map | GBrowse

	View Computational GO annotations for LCD1
Molecular Function
Manually curated	damaged DNA binding (IDA)
Biological Process
Manually curated	DNA damage checkpoint (IMP, IPI) establishment of protein localization (IDA, IMP) telomere maintenance via telomerase (IMP)
Cellular Component
Manually curated	nuclear chromosome (IDA)
High-throughput	nucleus (IDA)

Classical genetics
null	inviable
overexpression	cell cycle progression: normal cell cycle progression through the G2/M phase transition: arrested viability: decreased
Large-scale survey
null	haploinsufficient inviable vegetative growth: decreased
reduction of function	competitive fitness: decreased resistance to methyl methanesulfonate: decreased resistance to hydroxyurea: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	75 total interaction(s) for 41 unique genes/features.
Physical Interactions	Affinity Capture-MS: 15 Affinity Capture-RNA: 1 Affinity Capture-Western: 11 Biochemical Activity: 2 Co-localization: 2 PCA: 1 Reconstituted Complex: 5 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 9 Dosage Lethality: 3 Dosage Rescue: 2 Phenotypic Enhancement: 3 Phenotypic Suppression: 8 Synthetic Growth Defect: 2 Synthetic Lethality: 7 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1447830 to 1450073 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2244 1447830..1450073 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002907