Standard Name	ITR1
Systematic Name	YDR497C
Feature Type	ORF, Verified
Description	Myo-inositol transporter; member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress; ITR1 has a paralog, ITR2, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	myo-Inositol TRansporter 2

Chromosomal Location	ChrIV:1445467 to 1443713 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for ITR1
Molecular Function
Manually curated	myo-inositol transmembrane transporter activity (IMP, ISS)
Biological Process
Manually curated	myo-inositol transport (IMP) transmembrane transport (IMP)
Cellular Component
Manually curated	membrane (ISS) plasma membrane (IDA)
High-throughput	fungal-type vacuole membrane (IDA) integral to membrane (ISM) plasma membrane (IDA)

Classical genetics
null	heat sensitivity: increased
overexpression	cell cycle progression in G2 phase: abnormal
Large-scale survey
null	glutathione excretion: increased inositol excretion: increased competitive fitness: increased haploinsufficient resistance to quinine: decreased resistance to sodium arsenite: decreased resistance to 5-fluorouracil: decreased resistance to amitrole: decreased resistance to cisplatin: increased resistance to cycloheximide: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	89 total interaction(s) for 76 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-RNA: 1 PCA: 18 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 2 Negative Genetic: 25 Phenotypic Enhancement: 8 Phenotypic Suppression: 2 Positive Genetic: 8 Synthetic Growth Defect: 10 Synthetic Lethality: 3 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1445467 to 1443713 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1755 1445467..1443713 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000002905