ITR1/YDR497C Summary

ITR1 BASIC INFORMATION

Standard Name	ITR1
Systematic Name	YDR497C
Feature Type	ORF, Verified
Description	Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p (1, 2, 3)
Name Description	myo-Inositol TRansporter 2

GO Annotations	All ITR1 GO evidence and references
	View Computational GO annotations for ITR1
Molecular Function
Manually curated	myo-inositol transmembrane transporter activity (IMP, ISS)
Biological Process
Manually curated	myo-inositol transport (IMP) transmembrane transport (IMP)
Cellular Component
Manually curated	membrane (ISS) plasma membrane (IDA)

Mutant Phenotype	All ITR1 Phenotype details and references
Classical genetics
overexpression	cell cycle progression in G2 phase: abnormal
Large-scale survey
null	inositols excretion: increased resistance to cisplatin: increased viable
overexpression	vegetative growth: decreased

Interactions	ITR1 All interactions details and references
	32 total interaction(s) for 31 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 PCA: 15 Two-hybrid: 3
Genetic Interactions	Synthetic Growth Defect: 9 Synthetic Lethality: 4

Sequence Information

ChrIV:1445460 to 1443706 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1755	1445460..1443706	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| TCDB \| UniProtKB

Primary SGDID	S000002905

ITR1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ITR1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ITR1]

1)	Lai K and McGraw P (1994) Dual control of inositol transport in Saccharomyces cerevisiae by irreversible inactivation of permease and regulation of permease synthesis by INO2, INO4, and OPI1. J Biol Chem 269(3):2245-51
2)	Nikawa J, et al. (1991) Isolation and characterization of two distinct myo-inositol transporter genes of Saccharomyces cerevisiae. J Biol Chem 266(17):11184-91
3)	Nikawa J, et al. (1993) Differential regulation of two myo-inositol transporter genes of Saccharomyces cerevisiae. Mol Microbiol 10(5):955-61

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