PUF6/YDR496C Summary

PUF6 BASIC INFORMATION

Standard Name	PUF6
Systematic Name	YDR496C
Feature Type	ORF, Verified
Description	Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences in the 3' UTR and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA (1)
Name Description	PUmilio-homology domain Family

GO Annotations	All PUF6 GO evidence and references
	View Computational GO annotations for PUF6
Molecular Function
Manually curated	mRNA binding (IDA) specific transcriptional repressor activity (IDA)
Biological Process
Manually curated	regulation of transcription, mating-type specific (IDA, IMP)
Cellular Component
High-throughput	nucleolus (IDA) nucleus (IDA)

Mutant Phenotype	All PUF6 Phenotype details and references
Large-scale survey
null	competitive fitness: decreased hyperosmotic stress resistance: decreased resistance to tenovin-6: decreased viable

Interactions	PUF6 All interactions details and references
	176 total interaction(s) for 115 unique genes/features.
Physical Interactions	Affinity Capture-MS: 135 Affinity Capture-RNA: 3 Affinity Capture-Western: 4 Biochemical Activity: 1 Co-fractionation: 1 Reconstituted Complex: 1
Genetic Interactions	Phenotypic Enhancement: 9 Phenotypic Suppression: 16 Synthetic Growth Defect: 3 Synthetic Lethality: 2 Synthetic Rescue: 1

Sequence Information

ChrIV:1443396 to 1441426 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1971	1443396..1441426	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002904

PUF6 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for PUF6

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PUF6]

1)	Gu W, et al. (2004) A new yeast PUF family protein, Puf6p, represses ASH1 mRNA translation and is required for its localization. Genes Dev 18(12):1452-65

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.