RIB3/YDR487C Summary Help

Standard Name RIB3 1, 2
Systematic Name YDR487C
Feature Type ORF, Verified
Description 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase); required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration (3, 4)
Name Description RIBoflavin biosynthesis 1
Chromosomal Location
ChrIV:1428980 to 1428354 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RIB3 GO evidence and references
  View Computational GO annotations for RIB3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 7 genes
Resources
Pathways
Classical genetics
unspecified
Large-scale survey
conditional
null
overexpression
reduction of function
Resources
13 total interaction(s) for 13 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 4
  • Biochemical Activity: 1
  • PCA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 2
  • Phenotypic Enhancement: 1
  • Positive Genetic: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 208
Molecular Weight (Da) 22,567
Isoelectric Point (pI) 5.61
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1428980 to 1428354 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..627 1428980..1428354 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002895
References cited on this page View Complete Literature Guide for RIB3
1) Oltmanns O and Bacher A  (1972) Biosynthesis of riboflavine in Saccharomyces cerevisiae: the role of genes rib 1 and rib 7 . J Bacteriol 110(3):818-22
2) Revuelta, J.L., et al.  (1992) ; Personal Communication, Mortimer Map Edition 11
3) Garcia-Ramirez JJ, et al.  (1995) The Saccharomyces cerevisiae RIB4 gene codes for 6,7-dimethyl-8-ribityllumazine synthase involved in riboflavin biosynthesis. Molecular characterization of the gene and purification of the encoded protein. J Biol Chem 270(40):23801-7
4) Jin C, et al.  (2003) Yeast dihydroxybutanone phosphate synthase, an enzyme of the riboflavin biosynthetic pathway, has a second unrelated function in expression of mitochondrial respiration. J Biol Chem 278(17):14698-703