UGO1/YDR470C Summary Help

Standard Name UGO1 1
Systematic Name YDR470C
Feature Type ORF, Verified
Description Outer membrane component of the mitochondrial fusion machinery; binds directly to Fzo1p and Mgm1p and thus links these two GTPases during mitochondrial fusion; involved in fusion of both the outer and inner membranes; facilitates dimerization of Fzo1p during fusion; import into the outer membrane is mediated by Tom70p and Mim1p; has similarity to carrier proteins but is not likely to function as a transmembrane transporter (1, 2, 3, 4, 5, 6, 7)
Name Description UGO (Japanese for fusion) 1
Chromosomal Location
ChrIV:1401214 to 1399706 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All UGO1 GO evidence and references
  View Computational GO annotations for UGO1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
overexpression
Resources
65 total interaction(s) for 54 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 16
  • Reconstituted Complex: 2

Genetic Interactions
  • Dosage Growth Defect: 5
  • Negative Genetic: 18
  • Phenotypic Enhancement: 2
  • Positive Genetic: 18
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 502
Molecular Weight (Da) 57,543
Isoelectric Point (pI) 6.8
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1401214 to 1399706 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1509 1401214..1399706 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002878
References cited on this page View Complete Literature Guide for UGO1
1) Sesaki H and Jensen RE  (2001) UGO1 encodes an outer membrane protein required for mitochondrial fusion. J Cell Biol 152(6):1123-34
2) Sesaki H and Jensen RE  (2004) Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion. J Biol Chem 279(27):28298-303
3) Coonrod EM, et al.  (2007) Ugo1p is a multipass transmembrane protein with a single carrier domain required for mitochondrial fusion. Traffic 8(5):500-11
4) Hoppins S, et al.  (2009) Mitochondrial outer and inner membrane fusion requires a modified carrier protein. J Cell Biol 184(4):569-81
5) Anton F, et al.  (2011) Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion. J Cell Sci 124(Pt 7):1126-35
6) Papic D, et al.  (2011) Multispan mitochondrial outer membrane protein Ugo1 follows a unique Mim1-dependent import pathway. J Cell Biol 194(3):397-405
7) Becker T, et al.  (2011) The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins. J Cell Biol 194(3):387-95