SDC1/YDR469W Summary Help

Standard Name SDC1 1 (see Nomenclature conflict Note)
Systematic Name YDR469W
Alias CPS25 2 , SAF19 3
Feature Type ORF, Verified
Description Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30 (2, 4, 5, 6, 7, 8)
Name Description Set1c, homologue of Dpy30 from C.elegans
Chromosomal Location
ChrIV:1399015 to 1399542 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SDC1 GO evidence and references
  View Computational GO annotations for SDC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant phenotypes All SDC1 Phenotype evidence and references
Classical genetics
null
Large-scale survey
null
Resources
interactions All SDC1 Interaction evidence and references
352 total interaction(s) for 205 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 41
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 4
  • Co-crystal Structure: 1
  • Co-purification: 3
  • Reconstituted Complex: 1
  • Two-hybrid: 7
Genetic Interactions
  • Negative Genetic: 217
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 1
  • Positive Genetic: 17
  • Synthetic Growth Defect: 28
  • Synthetic Lethality: 21
  • Synthetic Rescue: 4
Resources
Expression Summary
histogram
Resources
Protein Information All SDC1 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1399015 to 1399542 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..528 1399015..1399542 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002877

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
GRR1Nomenclature conflictSDC1 has been used in the literature to refer to both SDC1/YDR469W and GRR1/YJR090C.
References cited on this page View Complete Literature Guide for SDC1
1) Samanta MP and Liang S  (2003) Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A 100(22):12579-83
2) Miller T, et al.  (2001) COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A 98(23):12902-7
3) Nagy PL, et al.  (2002) A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc Natl Acad Sci U S A 99(1):90-4
4) Roguev A, et al.  (2001) The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J 20(24):7137-48
5) Krogan NJ, et al.  (2002) COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem 277(13):10753-5
6) Sun ZW and Allis CD  (2002) Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature 418(6893):104-8
7) Dover J, et al.  (2002) Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem 277(32):28368-71
8) South PF, et al.  (2010) A conserved interaction between the SDI domain of Bre2 and the Dpy-30 domain of Sdc1 is required for histone methylation and gene expression. J Biol Chem 285(1):595-607