TLG1/YDR468C Summary

TLG1 BASIC INFORMATION

Standard Name	TLG1
Systematic Name	YDR468C
Feature Type	ORF, Verified
Description	Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p (1, 2)
Name Description	TSNARE that affects a Late Golgi compartment

GO Annotations	All TLG1 GO evidence and references
	View Computational GO annotations for TLG1
Molecular Function
Manually curated	SNAP receptor activity (IDA, TAS)
Biological Process
Manually curated	vesicle fusion (TAS)
Cellular Component
Manually curated	early endosome (TAS) Golgi trans cisterna (TAS) trans-Golgi network (TAS)

Mutant Phenotype	All TLG1 Phenotype details and references
Classical genetics
null	GFP-Snc1p accumulation: abnormal
Large-scale survey
null	inviable
overexpression	inviable

Interactions	TLG1 All interactions details and references
	55 total interaction(s) for 25 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 1 Affinity Capture-Western: 26 Biochemical Activity: 2 Co-crystal Structure: 1 Co-purification: 3 FRET: 1 Reconstituted Complex: 7 Two-hybrid: 6
Genetic Interactions	Dosage Lethality: 1 Phenotypic Enhancement: 1 Synthetic Growth Defect: 2 Synthetic Lethality: 2

Sequence Information

ChrIV:1398693 to 1398019 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..675	1398693..1398019	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002876

TLG1 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for TLG1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TLG1]

1)	Coe JG, et al. (1999) A role for Tlg1p in the transport of proteins within the Golgi apparatus of Saccharomyces cerevisiae. Mol Biol Cell 10(7):2407-23
2)	Siniossoglou S and Pelham HR (2002) Vps51p links the VFT complex to the SNARE Tlg1p. J Biol Chem 277(50):48318-24

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