PKH3/YDR466W Summary Help

Standard Name PKH3
Systematic Name YDR466W
Feature Type ORF, Verified
Description Protein kinase with similarity to mammalian PDK1 and yeast Pkh1p/Phk2p; yeast Pkh1p and Pkh2p are two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant (1)
Name Description Pkb-activating Kinase Homolog
Chromosomal Location
ChrIV:1395121 to 1397817 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PKH3 GO evidence and references
  View Computational GO annotations for PKH3
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Regulators 3 genes
Resources
Large-scale survey
null
Resources
83 total interaction(s) for 66 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 14
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Biochemical Activity: 6
  • Reconstituted Complex: 20
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 25
  • Positive Genetic: 14
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 898
Molecular Weight (Da) 100,475
Isoelectric Point (pI) 10.32
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1395121 to 1397817 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2697 1395121..1397817 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002874
References cited on this page View Complete Literature Guide for PKH3
1) Inagaki M, et al.  (1999) PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast. Mol Cell Biol 19(12):8344-52