Standard Name	MRPL28 1
Systematic Name	YDR462W
Feature Type	ORF, Verified
Description	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress (1, 2, 3)
Name Description	Mitochondrial Ribosomal Protein, Large subunit 1
Gene Product Alias	YmL28 1

Chromosomal Location	ChrIV:1386073 to 1386516 | ORF Map | GBrowse

	View Computational GO annotations for MRPL28
Molecular Function
Manually curated	structural constituent of ribosome (IDA)
Biological Process
Manually curated	mitochondrial translation (IC)
Cellular Component
Manually curated	mitochondrial large ribosomal subunit (IDA)
High-throughput	mitochondrion (IDA)

Large-scale survey
null	glycogen accumulation: decreased glutathione excretion: increased competitive fitness: decreased dessication resistance: decreased resistance to benomyl: decreased resistance to trichothecene: increased resistance to cycloheximide: decreased resistance to fluconazole: decreased resistance to quinine: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased resistance to elesclomol-Cu: decreased respiratory growth: absent respiratory growth: decreased rate stress resistance: increased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	52 total interaction(s) for 36 unique genes/features.
Physical Interactions	Affinity Capture-MS: 44 Affinity Capture-RNA: 2
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Synthetic Growth Defect: 2 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1386073 to 1386516 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..444 1386073..1386516 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002870