TFB3/YDR460W Summary

TFB3 BASIC INFORMATION

Standard Name	TFB3
Systematic Name	YDR460W
Alias	RIG2
Feature Type	ORF, Verified
Description	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit (1, 2, 3)
Name Description	Transcription initiation Factor IIB

GO Annotations	All TFB3 GO evidence and references
	View Computational GO annotations for TFB3
Molecular Function
Manually curated	general RNA polymerase II transcription factor activity (TAS)
Biological Process
Manually curated	negative regulation of transcription from RNA polymerase II promoter, mitotic (TAS) nucleotide-excision repair (IMP) nucleotide-excision repair, DNA duplex unwinding (TAS) transcription initiation from RNA polymerase II promoter (TAS)
Cellular Component
Manually curated	holo TFIIH complex (IDA) nucleotide-excision repair factor 3 complex (TAS) TFIIK complex (IDA)

Mutant Phenotype	All TFB3 Phenotype details and references
Classical genetics
conditional	UV resistance: decreased heat sensitivity: increased
reduction of function	resistance to caffeine: decreased
Large-scale survey
null	inviable

Interactions	TFB3 All interactions details and references
	31 total interaction(s) for 9 unique genes/features.
Physical Interactions	Affinity Capture-MS: 18 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Co-purification: 4 Two-hybrid: 4
Genetic Interactions	Synthetic Lethality: 2

Sequence Information

ChrIV:1383804 to 1384769 | |

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..966	1383804..1384769	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002868

TFB3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for TFB3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TFB3]

1)	Feaver WJ, et al. (1997) Genes for Tfb2, Tfb3, and Tfb4 subunits of yeast transcription/repair factor IIH. Homology to human cyclin-dependent kinase activating kinase and IIH subunits. J Biol Chem 272(31):19319-27
2)	Prakash S and Prakash L (2000) Nucleotide excision repair in yeast. Mutat Res 451(1-2):13-24
3)	Lee TI and Young RA (2000) Transcription of eukaryotic protein-coding genes. Annu Rev Genet 34:77-137

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