Standard Name	TFB3
Systematic Name	YDR460W
Alias	RIG2
Feature Type	ORF, Verified
Description	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit (1, 2, 3)
Name Description	Transcription initiation Factor IIB

Chromosomal Location	ChrIV:1383811 to 1384776 | ORF Map | GBrowse

	View Computational GO annotations for TFB3
Molecular Function
Manually curated	contributes_to core RNA polymerase binding transcription factor activity (IC)
Biological Process
Manually curated	nucleotide-excision repair (IMP) phosphorylation of RNA polymerase II C-terminal domain (IDA) transcription from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	holo TFIIH complex (IDA) TFIIK complex (IDA)

Classical genetics
conditional	UV resistance: decreased heat sensitivity: increased
reduction of function	resistance to caffeine: decreased
Large-scale survey
conditional	colony sectoring: increased
null	haploinsufficient inviable
reduction of function	competitive fitness: increased
repressible	chromosome/plasmid maintenance: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	81 total interaction(s) for 25 unique genes/features.
Physical Interactions	Affinity Capture-MS: 21 Affinity Capture-RNA: 1 Affinity Capture-Western: 20 Co-crystal Structure: 9 Co-localization: 1 Co-purification: 15 Reconstituted Complex: 3 Two-hybrid: 5
Genetic Interactions	Dosage Growth Defect: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1383811 to 1384776 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..966 1383811..1384776 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002868