Standard Name	YHP1 1
Systematic Name	YDR451C
Feature Type	ORF, Verified
Description	Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication (2, 3, 4)
Name Description	Yeast Homeo-Protein 1

Chromosomal Location	ChrIV:1362181 to 1361120 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for YHP1
Molecular Function
Manually curated	RNA polymerase II regulatory region sequence-specific DNA binding (IDA, IMP) RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription (IPI)
Biological Process
Manually curated	negative regulation of transcription from RNA polymerase II promoter (IMP) negative regulation of transcription involved in G1 phase of mitotic cell cycle (IGI)
Cellular Component
Manually curated	nuclear chromatin (IDA) nucleus (IC)

Binding motifs	Predicted YHP1 Binding Site Locations
	TAATTG 1 [Search intergenic regions for TAATTG]
Regulatory modules	predicted: stressResponse (529) predicted: cellcycle (329) predicted: stressResponse (529) predicted: cellcycle (329)
Resources	ScerTF | YEASTRACT | YeTFaSCo

Classical genetics
overexpression	actin cytoskeleton morphology: abnormal budding: abnormal cellular morphology: abnormal
Large-scale survey
null	anaerobic growth: decreased competitive fitness: increased competitive fitness: decreased dessication resistance: decreased haploproficient resistance to caffeine: decreased resistance to methyl methanesulfonate: increased stress resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	54 total interaction(s) for 53 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 11 Protein-RNA: 1 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 5 Negative Genetic: 22 Positive Genetic: 9 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1362181 to 1361120 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1062 1362181..1361120 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002859