ECM11/YDR446W Summary Help

Standard Name ECM11 1
Systematic Name YDR446W
Feature Type ORF, Verified
Description Meiosis-specific protein; component of the Synaptonemal Complex (SC) along with Gmc2p; required for efficient crossover formation and for the efficient loading of the SC transverse filament protein, Zip1p; is SUMOlytaed in a Gmc2p manner, and SUMOylation is required for its function in meiosis; GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure (2, 3, 4)
Name Description ExtraCellular Mutant 1
Chromosomal Location
ChrIV:1353725 to 1354633 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ECM11 GO evidence and references
  View Computational GO annotations for ECM11
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 44 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
unspecified
Resources
21 total interaction(s) for 15 unique genes/features.
Physical Interactions
  • Affinity Capture-Western: 3
  • Two-hybrid: 14

Genetic Interactions
  • Negative Genetic: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 1
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 302
Molecular Weight (Da) 34,113
Isoelectric Point (pI) 8.54
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1353725 to 1354633 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..909 1353725..1354633 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002854
References cited on this page View Complete Literature Guide for ECM11
1) Lussier M, et al.  (1997) Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae. Genetics 147(2):435-50
2) Comino A, et al.  (2001) Ecm11 is located in the cell nucleus throughout mitosis. Pflugers Arch 442(6 Suppl 1):R179-81
3) Zavec AB, et al.  (2004) The Saccharomyces cerevisiae gene ECM11 is a positive effector of meiosis. FEMS Microbiol Lett 241(2):193-9
4) Humphryes N, et al.  (2013) The Ecm11-Gmc2 complex promotes synaptonemal complex formation through assembly of transverse filaments in budding yeast. PLoS Genet 9(1):e1003194