LRS4/YDR439W Summary

LRS4 BASIC INFORMATION

Standard Name	LRS4 1
Systematic Name	YDR439W
Feature Type	ORF, Verified
Description	Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation (1, 2, 3)
Name Description	Loss of RDNA Silencing 1

GO Annotations	All LRS4 GO evidence and references
	View Computational GO annotations for LRS4
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	chromatin silencing at rDNA (IDA) homologous chromosome segregation (IMP, IPI) protein localization to nucleolar rDNA repeats (IMP) rDNA condensation (IMP)
Cellular Component
Manually curated	monopolin complex (IDA) nucleolus (IDA) nucleus (IDA)

Mutant Phenotype	All LRS4 Phenotype details and references
Classical genetics
null	chromosome/plasmid maintenance: abnormal colony sectoring: increased
Large-scale survey
null	competitive fitness: decreased mitotic recombination: increased Rad52-YFP distribution: increased sporulation: decreased viable

Interactions	LRS4 All interactions details and references
	246 total interaction(s) for 192 unique genes/features.
Physical Interactions	Affinity Capture-MS: 23 Affinity Capture-Western: 4 Biochemical Activity: 6 Co-localization: 1 Two-hybrid: 7
Genetic Interactions	Phenotypic Enhancement: 35 Phenotypic Suppression: 69 Synthetic Growth Defect: 81 Synthetic Lethality: 19 Synthetic Rescue: 1

Sequence Information

ChrIV:1339669 to 1340712 | |

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1044	1339669..1340712	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002847

LRS4 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for LRS4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for LRS4]

1)	Smith JS, et al. (1999) A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. Mol Cell Biol 19(4):3184-97
2)	Rabitsch KP, et al. (2003) Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I. Dev Cell 4(4):535-48
3)	Johzuka K and Horiuchi T (2009) The cis element and factors required for condensin recruitment to chromosomes. Mol Cell 34(1):26-35

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