LRS4/YDR439W Summary Help

Standard Name LRS4 1
Systematic Name YDR439W
Feature Type ORF, Verified
Description Nucleolar protein that forms a complex with Csm1p; and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation (1, 2, 3)
Name Description Loss of RDNA Silencing 1
Chromosomal Location
ChrIV:1339676 to 1340719 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All LRS4 GO evidence and references
  View Computational GO annotations for LRS4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
null
Large-scale survey
null
Resources
479 total interaction(s) for 359 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 68
  • Affinity Capture-Western: 6
  • Biochemical Activity: 6
  • Co-crystal Structure: 1
  • Co-localization: 3
  • Reconstituted Complex: 1
  • Two-hybrid: 11

Genetic Interactions
  • Negative Genetic: 155
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 3
  • Positive Genetic: 114
  • Synthetic Growth Defect: 83
  • Synthetic Lethality: 23
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 347
Molecular Weight (Da) 39,354
Isoelectric Point (pI) 10.34
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1339676 to 1340719 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1044 1339676..1340719 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002847
References cited on this page View Complete Literature Guide for LRS4
1) Smith JS, et al.  (1999) A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. Mol Cell Biol 19(4):3184-97
2) Rabitsch KP, et al.  (2003) Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I. Dev Cell 4(4):535-48
3) Johzuka K and Horiuchi T  (2009) The cis element and factors required for condensin recruitment to chromosomes. Mol Cell 34(1):26-35